|
KMID : 0603820150210030160
|
|
Journal of Experimental & Biomedical Science
2015 Volume.21 No. 3 p.160 ~ p.163
|
|
|
Short-term Hypothermia Induces Beta-catenin-interacting Protein 1 Gene Expression in PC12 Cells
|
|
Kwon Ki-sang
Yoo Bo-Kyung
Lee Eun-Ryeong
Kim Seung-Whan
Yu Kweon
Kwon O-Yu
|
|
|
Abstract
|
|
|
|
The effects of hypothermic treatment (32℃) on recovery from ischemia are controversial because the precise mechanisms of hypothermia remain unclear. We demonstrated previously that hypothermia induces beta-catenin-interacting protein 1 (CTNNBIP1) gene expression in vitro. In this study, we evaluated the effects of various hypothermic conditions, including lithium chloride treatment, on CTNNBIP1 gene expression. The results show that short-term hypothermic treatment resulted in relatively higher CTNNBIP1 gene expression than that of a longer treatment. These findings indicate that hypothermia controls CTNNBIP1 gene expression, which may provide clues to develop treatments to recover from and diagnose ischemia.
|
|
|
KEYWORD
|
|
|
Hypothermia, Beta-catenin-interacting protein 1(CTNNBIP1), PC12 cells
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|